Superparamagnetic Iron Oxide Nanoparticles: From Nanotoxicology to Biomedical Applications

13 March 2018

Boğaziçi-BME/Lifesci & Inovita & ISEK Joint Seminar

Superparamagnetic Iron Oxide NanoparticlesFrom Nanotoxicology to Biomedical Applications

Kurtuluş Gökduman, PhD

13 March 2018 (Tuesday);   13.00 – 14.00 

Institute of Biomedical Engineering, AZ-19,  Boğaziçi University Kandilli Campus

About The Seminar: Superparamagnetic iron oxide nanoparticles (SPIONs) are currently the only clinically approved metal oxide nanoparticles and the most commonly used superparamagnetic nanoparticles. SPIONs have a vast variety of biomedical applications including magnetic resonance imaging, targeted delivery of drugs/genes, tissue engineering, hyperthermia of cancer, magnetic transfections, among others. In parallel to their increasing use in clinical applications and the vast variety of their biomedical applications, safety concerns about SPIONs have increased and to date, there is neither adequate information regarding their safety nor standardized method to establish such parameters. Herein, a methodology for the design and biomedical applications of SPIONs with a focus on the obtained nanotoxicology data will be discussed.

About the Speaker: Dr. Kurtulus Gokduman received his B.Sc. degree in Biology, M.Sc. degree in Biotechnology, and Ph.D. degree in Biotechnology from Middle East Technical University, Ankara, Turkey. During his Ph.D. studies, he focused on the development of molecular genetic tools for Salmonella detection, as well as on the development of targeted and sustained delivery of Camptothecin anticancer drugs in bioactive form using iron oxide micro and nanoparticles. These researches have led to several publications and national/international patent applications. He performed post-doctoral research at Harvard Medical School, Harvard University, Boston, MA-USA, on the development of tumor on a chip test platform for bacterial cancer therapy, as well as on the investigation of hepatotoxicity profiles of super paramagnetic iron oxide nanoparticles using primary rat hepatocyte models. Currently his researches focus on cancer nanotechnology applications involving superparamagnetic iron oxide nanoparticles; early diagnosis of cancer and other diseases using miRNA expression levels; and the development of tumor/organ on a chip models for medical diagnostics, targeted drug delivery, drug screening, and toxicological studies.