"Standardizing Single-Voxel MR Spectroscopy across Vendors with Semi-LASER" Başlıklı Seminer
Boğaziçi-BME/Lifesci - İnovita - İSEK Ortak Semineri
Standardizing Single-Voxel MR Spectroscopy across Vendors with Semi-LASER
7 Ocak 2019 (Pazartesi); 13.00 – 14.00
Biyomedikal Mühendisliği Enstitüsü, AZ-19, Boğaziçi Üniversitesi Kandilli Kampüsü, İstanbul
Adam Berrington, PhD, Department of Neuroradiology, Johns Hopkins University
Host: Esin Öztürk Işık, PhD (Boğaziçi BME)
Wide clinical acceptance of MRS is dependent on reliable acquisition across sites and vendors. A recent consensus effort established the need for standardized protocols, which would allow multi-site, cross-platform studies on large patient cohorts. Previous studies have indicated variability in measured metabolite concentrations and sites and vendors vary in their implementation of MRS methods. Additionally, differences in hardware performance, sequence parameters and methodology pose a challenge for cross-vendor standardization. Localization with semi-LASER provides robust MRS measurement, with reduced chemical shift displacement and insensitivity to B1 inhomogeneity, and matched adiabatic refocusing has previously been demonstrated across vendors. In this talk, our efforts to implement the same semi-LASER schemes at 3 T on Siemens and Philips platforms, with identical sequence parameters and protocol, to assess the potential for reliable cross-vendor MRS acquisition will be presented.
Dr. Adam Berrington obtained his master's degree in Physics from University of Bristol. He moved to University of Oxford in 2012 to study for his PhD under the supervision Dr. Uzay Emir and Prof. Peter Jezzard at the Centre for Functional MRI of the Brain (FMRIB). His thesis title was 'Magnetic Resonance Spectroscopy of the in vivo brain with semi-LASER'. During this research, he focused largely on improving detection of 2-hydroxyglutarate in gliomas using semi-LASER MRS at 3 T, through the development of an optimised echo time sequence. He also explored the benefits of 2-HG detection at ultra-high field (7 T). Currently, he is working as a post-doctoral research scholar in the Johns Hopkins University Department of Neuroradiology since March 2017, where he works on general development of MRS acquisition methods at 3 T and 7 T.