"Towards the Clinical Utility of Raman Spectroscopy in Orthopaedic Diseases - from Osteoporosis to Osteoarthritis" Başlıklı Seminer
Boğaziçi-BME/Lifesci - İnovita - İSEK Ortak Semineri
Towards the Clinical Utility of Raman Spectroscopy in Orthopaedic Diseases - from Osteoporosis to Osteoarthritis
16 Ekim 2018 (Salı); 13.00 – 14.00
Biyomedikal Mühendisliği Enstitüsü, AZ-19, Boğaziçi Üniversitesi Kandilli Kampüsü, İstanbul
Mustafa Ünal, Ph.D.
Department of Orthopaedic Surgery and Rehabilitation, Vanderbilt Center for Bone Biology (VCBB), Vanderbilt University Medical Center, Vanderbilt Biophotonics Center (VBC),
Vanderbilt University, Nashville, TN, USA
Orthopaedic diseases such as osteoporosis and osteoarthritis have a growing socio-economic cost especially in the countries with aging populations. While the most widely used techniques for diagnosing these diseases utilize x-rays and MRI, these techniques cannot fully capture the molecular changes in extracellular matrix (ECM) of bone and cartilage. ECM quality is an essential contributor to the mechanical competence of bone and cartilage. Yet, there is an unmet need to develop a diagnostic tool that is sensitive to assess the molecular changes in ECM matrix that can be either the cause or the effect of diseases. With high chemical specificity and providing molecular information without requiring staining or labeling, Raman spectroscopy (RS) is an optical technique that can be used to develop a fundamental biochemical understanding of ECM and further extend this knowledge for tissue diagnosis and monitoring. In this presentation, I will share the progress we have made towards translating RS to the clinic to provide clinically meaningful measurements. Specifically, this presentation is going to focus on two recent biomedical applications of RS. The first application is a novel shortwave infrared Raman system that is specifically optimized for studying the high wavenumber range. High fidelity acquisition of Raman spectra in this range allowed us to measure the hydration of bone and cartilage, for the first time. The second application is a novel RS-based method to assess collagen matrix quality in bone, and the progress of its translation to the clinic.
Mustafa Unal is a Postdoctoral Research Fellow in the Department of Orthopaedic Surgery and Rehabilitation at Vanderbilt University Medical Center. Dr. Unal earned his Ph.D. (2017) and M.Sc. (2012) in Mechanical Engineering from Case Western Reserve University and The University of Texas, San Antonio, respectively, and his BS degree in Mechanical Engineering (2008) from Selcuk University. His research is at the interface of mechanical engineering, orthopaedics, and biomedical Raman spectroscopy, and seeks 1) to develop Raman spectroscopy techniques that provide clinical assessment of bone and cartilage quality, and 2) to identify age- and disease-related determinants affecting the resistance of bone to fracture. Throughout his PhD and Post-doctoral training, Dr. Unal received several national and international prestigious awards to recognize his success in the field. In 2018, Dr. Unal was selected as the finalist of Ten-Outstanding Young Persons of the World Award, in the category of Medical Innovation. Since 2014, Dr. Unal has authored 15 peer-reviewed articles, 1 book chapter, and presented 23 poster/oral presentations in top international conferences.